Structure of PDB 4chl Chain A

Receptor sequence
>4chlA (length=234) Species: 9606 (Homo sapiens) [Search protein sequence]
PVDAPILLRQMFEPVSCTFTYLLGDRESREAVLIDPVLETAPRDAQLIKE
LGLRLLYAVNTHCHADHITGSGLLRSLLPGCQSVISRLSGAQADLHIEDG
DSIRFGRFALETRASPGHTPGCVTFVLNDHSMAFTGDALLIRGCGRTDFQ
QGCAKTLYHSVHEKIFTLPGDCLIYPAHDYHGFTVSTVEEERTLNPRLTL
SCEEFVKIMGNLNLPKPQQIDFAVPANMRCGVQT
3D structure
PDB4chl Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy.
ChainA
Resolution2.61 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H79 H81 D83 H84 H135 D154 H195
Catalytic site (residue number reindexed from 1) H62 H64 D66 H67 H118 D137 H178
Enzyme Commision number 1.13.11.18: persulfide dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H79 H135 D154 H62 H118 D137
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0050313 sulfur dioxygenase activity
GO:0051213 dioxygenase activity
Biological Process
GO:0006749 glutathione metabolic process
GO:0070813 hydrogen sulfide metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4chl, PDBe:4chl, PDBj:4chl
PDBsum4chl
PubMed25596185
UniProtO95571|ETHE1_HUMAN Persulfide dioxygenase ETHE1, mitochondrial (Gene Name=ETHE1)

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