Structure of PDB 4cf9 Chain A

Receptor sequence
>4cf9A (length=150) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLA
GRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEDGIPYNPQSQGVIESMN
KELKKIIGQVRDQAEHLKTAVQMAVFIHNHKRKGYSAGERIVDIIATDIQ
3D structure
PDB4cf9 Interrogating HIV Integrase for Compounds that Bind- a Sampl Challenge.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 5EY A E170 H171 K173 T174 M178 E115 H116 K118 T119 M123
BS02 EE2 A Q168 A169 E170 H171 K173 T174 M178 Q113 A114 E115 H116 K118 T119 M123
BS03 5EY A Q95 A129 Q40 A74
BS04 EE2 A Q95 E96 Y99 L102 A129 Q40 E41 Y44 L47 A74
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
Biological Process
GO:0015074 DNA integration

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Molecular Function
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Biological Process
External links
PDB RCSB:4cf9, PDBe:4cf9, PDBj:4cf9
PDBsum4cf9
PubMed24532034
UniProtP12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)

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