Structure of PDB 4cd4 Chain A

Receptor sequence
>4cd4A (length=367) Species: 498211 (Cellvibrio japonicus Ueda107) [Search protein sequence]
LPALIDTQATAETRALYRNLAKLRYKHLLFGHEDSLAYGVHWEGDMDRSD
VRDVTGANPAVYGWELGGLELGHTANLDAVNFEKMQHWIKAGYSRGGVIT
ISWHVFNPVSGGNSWDKTPAVHELIPGGARHATLKAYLDTFVAFNEGLAD
VDAQGNKHYPPIIFRPWHEHNGDWFWWGKGHASEQDYIALWRFTVHYLRD
EKKLRNLIYAYSPDRSRIDMANFEAGYLYGYPGDAYVDIIGLDNYWDVGH
EANTASADEQKAALTASLKQLVQIARSKGKIAALTETGNNRLTIDNFWTE
RLLGPISADADASEIAYVMVWRNANLAREKSEQFFAPFPGQATADDFKRF
YQSEVVLFEDELPPLYR
3D structure
PDB4cd4 Combined Inhibitor Free-Energy Landscape and Structural Analysis Reports on the Mannosidase Conformational Coordinate.
ChainA
Resolution1.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.78: mannan endo-1,4-beta-mannosidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BMA A D130 W373 R374 Q385 D78 W321 R322 Q333 PDBbind-CN: -logKd/Ki=6.58,Ki=263nM
BS02 IFM A H156 E221 Y297 E338 W373 H104 E169 Y245 E286 W321 PDBbind-CN: -logKd/Ki=6.58,Ki=263nM
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016985 mannan endo-1,4-beta-mannosidase activity
Biological Process
GO:0006080 substituted mannan metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:4cd4, PDBe:4cd4, PDBj:4cd4
PDBsum4cd4
PubMed24339341
UniProtB3PGI1

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