Structure of PDB 4cb0 Chain A

Receptor sequence
>4cb0A (length=240) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
QEFLAAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLR
RRSGESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWS
EVLDNAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYS
HTKIEVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDEARDRESG
GTGLGLAIVETAIQQHRGWVKAEDSPLGGLRLVIWLPLYK
3D structure
PDB4cb0 Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation.
ChainA
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.13.3: histidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A N360 Y364 V391 R405 T406 T417 G420 L421 L445 N145 Y149 V176 R190 T191 T202 G205 L206 L230
Gene Ontology
Molecular Function
GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0007165 signal transduction
GO:0016310 phosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4cb0, PDBe:4cb0, PDBj:4cb0
PDBsum4cb0
PubMed24492262
UniProtP0AE82|CPXA_ECOLI Sensor histidine kinase CpxA (Gene Name=cpxA)

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