Structure of PDB 4cav Chain A

Receptor sequence

>4cavA (length=392) Species: 746128 (Aspergillus fumigatus)

GGPIKIIDPEKVSKEPDALLEGFEWATLDLTNETELQELWDLLTYHYVED
DNAMFRFRYSQSFLHWALMSPGWKKEWHVGVRATKSRKLVASICGVPTEI
NVRNQKLKVVEINFLCIHKKLRSKRLTPVLIKEITRRCYLNGIYQAIYTA
GVVLPTPVSSCRYYHRPLDWLKLYEVGFSPLPAGSTKARQITKNHLPSTT
STPGLRPMEPKDIDTVHDLLQRYLSRFALNQAFTREEVDHWLVHKPETVK
EQVVWAYVVEDPETHKITDFFSFYNLESTVIQNPKHDNVRAAYLYYYATE
TAFTNNMKALKERLLMLMNDALILAKKAHFDVFNALTLHDNPLFLEQLKF
GAGDGQLHFYLYNYRTAPVPGGVNEKNLPDEKRMGGVGIVML

3D structure

• PDB: 4cav N-Myristoyltransferase is a Cell Wall Target in Aspergillus Fumigatus.
• Chain: A
• Resolution: 1.89 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): N213 F214 L215 T249 L492
• Catalytic site (residue number reindexed from 1): N113 F114 L115 T149 L392
• Enzyme Commision number: 2.3.1.97: glycylpeptide N-tetradecanoyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2XQ	A	Y147 F155 F157 Y159 F214 Y263 H265 F278 L376 V389 Y393 V432 N434 A435 L492	Y47 F55 F57 Y59 F114 Y163 H165 F178 L276 V289 Y293 V332 N334 A335 L392
BS02	MYA	A	Y147 V148 I212 N213 L215 C216 I217 R222 S223 R225 T227 I231 T235 C238 Y244 A246 Y248 T249 V252 Y462	Y47 V48 I112 N113 L115 C116 I117 R122 S123 R125 T127 I131 T135 C138 Y144 A146 Y148 T149 V152 Y362

Gene Ontology

Molecular Function

• GO:0004379 glycylpeptide N-tetradecanoyltransferase activity

Biological Process

• GO:0006499 N-terminal protein myristoylation

External links

• PDB: RCSB:4cav, PDBe:4cav, PDBj:4cav
• PDBsum: 4cav
• PubMed: 25706802
• UniProt: Q9UVX3|NMT_ASPFU Glycylpeptide N-tetradecanoyltransferase (Gene Name=nmt1)