Structure of PDB 4ca6 Chain A

Receptor sequence
>4ca6A (length=608) Species: 9606 (Homo sapiens) [Search protein sequence]
LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAEN
ARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGS
ANLPLAKRQQYNALLSQMSRIYSTAKVCLKTATCWSLDPDLTNILASSRS
YAMLLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWY
NSPTFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHL
LGDMWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFT
SLELSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVT
MDQLSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTP
EHLHKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSG
RTPPSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYF
VSFVLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPW
QEVLKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPP
LPDNYPEG
3D structure
PDB4ca6 Crystal structures of highly specific phosphinic tripeptide enantiomers in complex with the angiotensin-I converting enzyme.
ChainA
Resolution1.91 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H331 A332 H361 E362 H365 E389 H491 Y501
Catalytic site (residue number reindexed from 1) H329 A330 H359 E360 H363 E387 H489 Y499
Enzyme Commision number 3.4.15.1: peptidyl-dipeptidase A.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H361 H365 E389 H359 H363 E387
BS02 3EF A Q259 H331 A332 S333 S357 T358 H361 E362 H365 Y369 H388 E389 D393 E431 F435 K489 F490 H491 T496 Y498 Y501 F505 Q257 H329 A330 S331 S355 T356 H359 E360 H363 Y367 H386 E387 D391 E429 F433 K487 F488 H489 T494 Y496 Y499 F503 MOAD: Ki=180nM
PDBbind-CN: -logKd/Ki=6.74,Ki=180nM
BindingDB: Ki=0.41nM
Gene Ontology
Molecular Function
GO:0008237 metallopeptidase activity
GO:0008241 peptidyl-dipeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:4ca6, PDBe:4ca6, PDBj:4ca6
PDBsum4ca6
PubMed24289879
UniProtP12821|ACE_HUMAN Angiotensin-converting enzyme (Gene Name=ACE)

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