Structure of PDB 4ca1 Chain A

Receptor sequence
>4ca1A (length=189) Species: 9606 (Homo sapiens) [Search protein sequence]
ANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQGS
LDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFM
LVLEKQEKHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSI
HEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB4ca1 Two High-Resolution Structures of the Human E3 Ubiquitin Ligase Siah1.
ChainA
Resolution1.58 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C98 C105 H117 C121 C8 C15 H27 C31
BS02 ZN A C128 C135 H147 H152 C38 C45 H57 H62
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4ca1, PDBe:4ca1, PDBj:4ca1
PDBsum4ca1
PubMed24316825
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

[Back to BioLiP]