Structure of PDB 4c9z Chain A

Receptor sequence
>4c9zA (length=193) Species: 9606 (Homo sapiens) [Search protein sequence]
MANSVLFPCKYASSGCEITLPHTEKADHEELCEFRPYSCPCPGASCKWQG
SLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHF
MLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEAT
PRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
3D structure
PDB4c9z Two High-Resolution Structures of the Human E3 Ubiquitin Ligase Siah1.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C128 C135 H147 H152 C39 C46 H58 H63
BS02 ZN A C98 C105 H117 C121 C9 C16 H28 C32
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007275 multicellular organism development
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c9z, PDBe:4c9z, PDBj:4c9z
PDBsum4c9z
PubMed24316825
UniProtQ8IUQ4|SIAH1_HUMAN E3 ubiquitin-protein ligase SIAH1 (Gene Name=SIAH1)

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