Structure of PDB 4c8z Chain A

Receptor sequence
>4c8zA (length=238) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MVLAALVLVLEGEGLPEPLGLRGFFYGLLREVAPEVHDQGENPFALGFGG
REGAAWARVSLLVEGLYARLAPRLYALEGEEVRLGPPFRVRAVLQEGHPW
AGVSTYPRLFQGPPSRDLALRFASPTFFRRKGVHYPVPEPRLVLESLLRR
LEAFGPLKAPEGVREALLERTTVRSLEGRTLPARTEVDTAGFVGRVVYHL
PRATEEEALWLSALGRFAFYSGVGAKTSLGYGRARAES
3D structure
PDB4c8z Evolution of Crispr RNA Recognition and Processing by Cas6 Endonucleases.
ChainA
Resolution2.503 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A R22 Y26 H37 Q39 G40 F128 R129 R130 V133 H134 L142 E145 R149 E186 V187 D188 A225 K226 S228 R22 Y26 H37 Q39 G40 F128 R129 R130 V133 H134 L142 E145 R149 E186 V187 D188 A225 K226 S228 PDBbind-CN: Kd=90pM
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:4c8z, PDBe:4c8z, PDBj:4c8z
PDBsum4c8z
PubMed24150936
UniProtQ5SM65

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