Structure of PDB 4c8b Chain A

Receptor sequence
>4c8bA (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
SALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLD
SERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELL
HRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNE
FHVKIADFGTIIYMPPENYSIKHDIYSYAVITWEVLSRKQPFEDVTNPLQ
IMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCL
IELEPVLRTFEEITFLEAVIQLKKTKLQS
3D structure
PDB4c8b Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R22 D146 K148 Q150 N151 D164 T189
Catalytic site (residue number reindexed from 1) R15 D139 K141 Q143 N144 D157 T160
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0LI A A45 K47 E66 L70 L79 I93 T95 M98 L143 H144 L153 I162 A163 D164 F165 A38 K40 E59 L63 L72 I86 T88 M91 L136 H137 L146 I155 A156 D157 F158 BindingDB: IC50=1.000000nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4c8b, PDBe:4c8b, PDBj:4c8b
PDBsum4c8b
PubMed26320862
UniProtO43353|RIPK2_HUMAN Receptor-interacting serine/threonine-protein kinase 2 (Gene Name=RIPK2)

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