Structure of PDB 4c7o Chain A

Receptor sequence
>4c7oA (length=293) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
NLTDRLSRTLRNISGRGRLTEDNVKDTLREVRMALLEADVALPVVREFIN
RVKEKAVGHEVNKSLTPGQEFVKIVRNELVAAMGEENQTLNLAAQPPAVV
LMAGLQGAGKTTSVGKLGKFLREKHKKKVLVVSADVYRPAAIKQLETLAE
QVGVDFFPSDVGQKPVDIVNAALKEAKLKFYDVLLVDTAGRLHVDEAMMD
EIKQVHASINPVETLFVVDAMTGQDAANTAKAFNEALPLTGVVLTKVDGD
ARGGAALSIRHITGKPIKFLGVGEKTEALEPFHPDRIASRILG
3D structure
PDB4c7o The Structural Basis of Ftsy Recruitment and Gtpase Activation by Srp RNA
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.4: signal-recognition-particle GTPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A E277 K278 E274 K275 PDBbind-CN: Kd~0.5uM
BS02 ALF A Q109 G110 K113 D138 R141 G193 Q106 G107 K110 D135 R138 G190
BS03 GDP A G110 G112 K113 T114 T115 R141 K249 D251 G274 G276 E277 G107 G109 K110 T111 T112 R138 K246 D248 G271 G273 E274
BS04 GDP A Q109 R141 Q106 R138
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
Cellular Component
GO:0048500 signal recognition particle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c7o, PDBe:4c7o, PDBj:4c7o
PDBsum4c7o
PubMed24211265
UniProtP0AGD7|SRP54_ECOLI Signal recognition particle protein (Gene Name=ffh)

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