Structure of PDB 4c7f Chain A

Receptor sequence

>4c7fA (length=494) Species: 1902 (Streptomyces coelicolor)

AEPTPLDRVIPAPASVEPGGAPYRITRGTHIRVDDSREARRVGDYLADLL
RPATGYRLPVTSHGHGGIRLRLAEGPYGDEGYRLDSGREGVTITARKAAG
LFHGVQTLRQLLPAAVEKDSAQPGPWLVAGGTIEDTPRYAWRSAMLDVSR
HFFSVDEVKRYIDRVALYKYNKLHLHISDDQGWRLAIDSWPRLATYGGST
EVGGGPGGHYTKADYEEIVRYAASRHLEVVPEIDMPGHTNAALASYAELN
CDGVAPPLYTGTKVGFSTLCVDKDVTYDFVDDVLGELAALTPGRYLHIGG
DEAHSTPQADFVAFMKRVQPIVAKYGKTVVGWHQLAGAEPVEGALVQYWG
LDRTSDAEKAQVAAAARNGTGLILSPADRTYLDMKYTKDTPLGLSWAGYV
EVRRSYDWDPAAYLPGAPAEAVRGVEAPLWTETLSDPDQLDFMAFPRLPG
VAELGWSPASTHDWDTYKVRLAGQAPHWEAMGIDYYRSPQVPWT

3D structure

• PDB: 4c7f Structure and Activity of the Streptomyces Coelicolor A3(2) Beta-N-Acetylhexosaminidase Provides Further Insight Into Gh20 Family Catalysis and Inhibition.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D301 E302
• Catalytic site (residue number reindexed from 1): D301 E302
• Enzyme Commision number: 3.2.1.52: beta-N-acetylhexosaminidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GC2	A	R150 D301 E302 W332 W349 Y381 W396 W430 E432	R150 D301 E302 W332 W349 Y381 W396 W430 E432

Gene Ontology

Molecular Function

• GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
• GO:0004563 beta-N-acetylhexosaminidase activity
• GO:0016787 hydrolase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0030203 glycosaminoglycan metabolic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4c7f, PDBe:4c7f, PDBj:4c7f
• PDBsum: 4c7f
• PubMed: 24559145
• UniProt: Q9L068