Structure of PDB 4c78 Chain A

Receptor sequence
>4c78A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSDLPYPEAIFELP
FFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGL
ERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVC
TGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEA
VRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEM
RDLVQRETGKL
3D structure
PDB4c78 Crystal Structures of Sirt3 Complexes with 4'-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 F157 R158 N229 D231 H248
Catalytic site (residue number reindexed from 1) P34 D35 F36 R37 N96 D98 H115
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R158 E177 F180 H248 V292 F294 G295 E296 L298 R37 E44 F47 H115 V159 F161 G162 E163 L165
BS02 BVB A R139 M311 R335 R18 M178 R202
BS03 ZN A C256 C259 C280 C283 C123 C126 C147 C150
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:4c78, PDBe:4c78, PDBj:4c78
PDBsum4c78
PubMed24211137
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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