Structure of PDB 4c4n Chain A

Receptor sequence
>4c4nA (length=151) Species: 10090 (Mus musculus) [Search protein sequence]
LTPLAYKQFIPNVAEKTLGASGRYEGKITRNSERFKELTPNYNPDIIFKD
EENTGADRLMTQRCKDKLNALAISVMNQWPGVKLRVTEGWDEDGHHSEES
LHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESKAHIHCSVKAE
N
3D structure
PDB4c4n Structural Insights Into Proteoglycan-Shaped Hedgehog Signaling.
ChainA
Resolution2.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.-.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IDS A K88 R124 R154 K49 R85 R115 PDBbind-CN: -logKd/Ki=6.10,Kd=0.8uM
BS02 SGN A K88 R124 K49 R85 PDBbind-CN: -logKd/Ki=6.10,Kd=0.8uM
BS03 ZN A H141 D148 H183 H102 D109 H144
BS04 CA A E91 E127 D130 D132 H134 E52 E88 D91 D93 H95
BS05 CA A E90 E91 D96 T126 E127 E51 E52 D57 T87 E88
Gene Ontology
Biological Process
GO:0007267 cell-cell signaling
GO:0007275 multicellular organism development

View graph for
Biological Process
External links
PDB RCSB:4c4n, PDBe:4c4n, PDBj:4c4n
PDBsum4c4n
PubMed24062467
UniProtQ62226|SHH_MOUSE Sonic hedgehog protein (Gene Name=Shh)

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