Structure of PDB 4c49 Chain A

Receptor sequence
>4c49A (length=367) Species: 9606 (Homo sapiens) [Search protein sequence]
GLASANVDFAFSLYKHLVALSPKKNIFISPVSISMALAMLSLGTCGHTRA
QLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMGNALFLDGSL
ELLESFSADIKHYYESEVLAMNFQDWATASRQINSYVKNKTQGKIVDLFS
GLDSPAILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQS
STISYLHDSELPCQLVQMNYVGNGTVFFILPDKGKMNTVIAALSRDTINR
WSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMGIADLFTNQANFSRITQD
AQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLRKPIILRFNQPFIIMIF
DHFTWSSLFLARVMNPV
3D structure
PDB4c49 Role of Sa-Hd Loop Movement in Cortisol Release Mechanism of Cbg
ChainA
Resolution2.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HCY A R260 I263 N264 S267 F366 H368 W371 R245 I248 N249 S252 F350 H352 W355 BindingDB: Ki=13nM
Gene Ontology
Molecular Function
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005496 steroid binding
Biological Process
GO:0008211 glucocorticoid metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c49, PDBe:4c49, PDBj:4c49
PDBsum4c49
PubMed
UniProtP08185|CBG_HUMAN Corticosteroid-binding globulin (Gene Name=SERPINA6)

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