Structure of PDB 4c30 Chain A

Receptor sequence

>4c30A (length=631) Species: 1299 (Deinococcus radiodurans)

PDLLQALNPTQAQAADHFTGPALVIAGAGSGKTRTLIYRIAHLIGHYGVH
PGEILAVTFTNKAAAEMRERAGHLVPGAGDLWMSTFHSAGVRILRTYGEH
IGLRRGFVIYDDDDQLDIIKEVMGSIPGIGAETQPRVIRGIIDRAKSNLW
TPDDLDRSREPPRDAAAEAYRRYEVRKKGQNAIDFGDLITETVRLFKEVP
GVLDKVQNKAKFIHVDEYQDTNRAQYELTRLLASRDRNLLVVGDPDQSIY
KFRGADIQNILDFQKDYPDAKVYMLEHNYRSSARVLEAANKLIENNTERL
DKTLKPVKEAGQPVTFHRATDHRAEGDYVADWLTRLHGEGRAWSEMAILY
RTNAQSRVIEESLRRVQIPARIVGGVGFYDRREIRDILAYARLALNPADD
VALRRIIGRPRRGIGDTALQKLMEWARTHHTSVLTACANAHKATEFAGLM
EAMSEAADNYEPAAFLRFVMETSGYLDLLRQEGQEGQVRLENLEELVSAA
EEWSQDEAIADFLDDAALLSSVDDMRTKAEPEDAVTLMTLHNAKGLEFPV
VFIVGVEQGLLPSKGAIAEGPSGIEEERRLFYVGITRAMERLLMTAAQNR
MQFGKTNAAEDSAFLEDIEGLFDTVDPYGQP

3D structure

• PDB: 4c30 Structural and Mechanistic Insight Into DNA Unwinding by Deinococcus Radiodurans Uvrd.
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K38 T39 D227 E228 Q258 R617
• Catalytic site (residue number reindexed from 1): K32 T33 D216 E217 Q247 R587
• Enzyme Commision number: 5.6.2.4: DNA 3'-5' helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	R142 Y261 F263 R362 N364 R422 G424 I425 G426 T428 L544 S546 S547 T569 H571 S593 F633	R136 Y250 F252 R351 N353 R411 G413 I414 G415 T417 L518 S520 S521 T539 H541 S563 F603
BS02	dna	A	R393 F633	R382 F603
BS03	ANP	A	Q17 A34 G35 S36 G37 K38 T39 R40 Q258 Y290 R291 E577 R617	Q11 A28 G29 S30 G31 K32 T33 R34 Q247 Y279 R280 E547 R587
BS04	MG	A	D118 D391	D112 D380

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:4c30, PDBe:4c30, PDBj:4c30
• PDBsum: 4c30
• PubMed: 24143224
• UniProt: Q9RTI9