Structure of PDB 4c2u Chain A

Receptor sequence

>4c2uA (length=658) Species: 1299 (Deinococcus radiodurans)

SAGPDLLQALNPTQAQAADHFTGPALVIAGAGSGKTRTLIYRIAHLIGHY
GVHPGEILAVTFTNKAAAEMRERAGHLVPGAGDLWMSTFHSAGVRILRTY
GEHIGLRRGFVIYDDDDQLDIIKEVMGSIPGETQPRVIRGIIDRAKSNLW
TPDDLDRSREPFISGLPRDAAAEAYRRYEVRKKGQNAIDFGDLITETVRL
FKEVPGVLDKVQNKAKFIHVDEYQDTNRAQYELTRLLASRDRNLLVVGDP
DQSIYKFRGADIQNILDFQKDYPDAKVYMLEHNYRSSARVLEAANKLIEN
NTERLDKTLKPVKEAGQPVTFHRATDHRAEGDYVADWLTRLHGEGRAWSE
MAILYRTNAQSRVIEESLRRVQIPARIVGGVGFYDRREIRDILAYARLAL
NPADDVALRRIIGRPRRGIGDTALQKLMEWARTHHTSVLTACANAAEQNI
LDRGAHKATEFAGLMEAMSEAADNYEPAAFLRFVMETSGYLDLLRQEGQE
GQVRLENLEELVSAAEEWSQDEANVGGSIADFLDDAALLSSVDDMRTKAE
NKGAPEDAVTLMTLHNAKGLEFPVVFIVGVEQGLLPSKGAIAEGPSGIEE
ERRLFYVGITRAMERLLMTAAQNRMQFGKTNAAEDSAFLEDIEGLFDTVD
PYGQPIEY

3D structure

• PDB: 4c2u Structural and Mechanistic Insight Into DNA Unwinding by Deinococcus Radiodurans Uvrd.
• Chain: A
• Resolution: 2.55 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K38 T39 D227 E228 Q258 R617
• Catalytic site (residue number reindexed from 1): K35 T36 D221 E222 Q252 R611
• Enzyme Commision number: 5.6.2.4: DNA 3'-5' helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	F65 F196 Y261 F263 R264 R362 T363 N364 R422 R423 G424 I425 G426 T428 A429 S546 S547 T569 H571 Q632 F633	F62 F190 Y255 F257 R258 R356 T357 N358 R416 R417 G418 I419 G420 T422 A423 S540 S541 T563 H565 Q626 F627
BS02	ANP	A	Q17 G35 S36 G37 K38 T39 R40 Q258 Y290 R291 E577 R617	Q14 G32 S33 G34 K35 T36 R37 Q252 Y284 R285 E571 R611

Gene Ontology

Molecular Function

• GO:0003677 DNA binding
• GO:0003678 DNA helicase activity
• GO:0005524 ATP binding
• GO:0016787 hydrolase activity

External links

• PDB: RCSB:4c2u, PDBe:4c2u, PDBj:4c2u
• PDBsum: 4c2u
• PubMed: 24143224
• UniProt: Q9RTI9