Structure of PDB 4c2m Chain A

Receptor sequence
>4c2mA (length=1521) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
MDISKPVGSEITSVDFGILTAKEIRNLSAKQITNPTVLDNLGHPVSGGLY
DLALGAFLRNLCSTCGLDEKFCPGHQGHIELPVPCYNPLFFNQLYIYLRA
SCLFCHHFRLKSVEVHRYACKLRLLQYGLIDESYKLDEITLSSTLLNELK
SKRSEYVDMAIAKALSDGRTTERGSFTATVNDERKKLVHEFHKKLLSRGK
CDNCGMFSPKFRKDGFTKIFETALNEKQITNNRVKGFIRQDSTYILSTEV
KNILDTVFRKEQCVLQYVFHSRPNLSRKLVKADSFFMDVLVVPPTRFRLP
SKLGEEVHENSQNQLLSKVLTTSLLIRDLNDDLSKLQKDKVSLEDRRVIF
SRLMNAFVTIQNDVNAFIDSTKAQGRTSGKVPIPGVKQALEKKEGLFRKH
MMGKRVNYAARSVISPDPNIETNEIGVPPVFAVKLTYPEPVTAYNIAELR
QAVINGPDKWPGATQIQNEDGSLVSLIGMSVEQRKALANQLLTPSSNVST
HTLNKKVYRHIKNRDVVLMNRQPTLHKASMMGHKVRVLPNEKTLRLHYAN
TGAYNADFDGDEMNMHFPQNENARAEALNLANTDSQYLTPTSGSPVRGLI
QDHISAGVWLTSKDSFFTREQYQQYIYGCIRPEDGHTTRSKIVTLPPTIF
KPYPLWTGKQIITTVLLNVTPPDMPGINLISKNKIKNEYWGKGSLENEVL
FKDGALLCGILDKSQYGASKYGIVHSLHEVYGPEVAAKVLSVLGRLFTNY
ITATAFTCGMDDLRLTAEGNKWRTDILKTSVDTGREAAAEVTNLDKDTPA
DDPELLKRLQEILRDNNKSGILDAVTSSKVNAITSQVVSKCVPDGTMKKF
PCNSMQAMALSGAKGSNVNVSQIMCLLGQQALEGRRVPVMVSGKTLPSFK
PYETDAMAGGYVKGRFYSGIKPQEYYFHCMAGREGLIDTAVKTSRSGYLQ
RCLTKQLEGVHVSYDNSIRDADGTLVQFMYGGDAIDITKESHMTQFEFCL
DNYYALLKKYNPSALIEHLDVESALKYSKKTLKYRKKHSKEPHYKQSVKY
DPVLAKYNPAKYLGSVSENFQDKLESFLDKNSKLFKSSDGVNEKKFRALM
QLKYMRSLINPGEAVGIIASQSVGEPSTQMTLNTFANVTLGIPRLREIVM
TASAAIKTPQMTLPIWNDVSDEQADTFCKSISKVLLSEVIDKVIVTETTA
ARSYVIHMRFFDNNEYSEEYDVSKEELQNVISNQFIHLLEAAIVKEIKKQ
KRTPDIGVAVPNSKRLEEDNDEEQSHKKTKQAVSYDEPDEDEIETMNKVQ
RDRQSAIISHHRFITKYNFDDESGKWCEFKLELAADTEKLLMVNIVEEIC
RKSIIRQIPHIDRCVHPEPENGKRVLVTEGVNFQAMWDQEAFIDVDGITS
NDVAAVLKTYGVEAARNTIVNEINNVFSRYAISVSFRHLDLIADMMTRQG
TYLAFNRQGMETSTSSFMKMSYETTCQFLTKAVLDNEREQLDSPSARIVV
GKLNNVGTGSFDVLAKVPNAA
3D structure
PDB4c2m RNA Polymerase I Structure and Transcription Regulation.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C62 C65 C72 H75 C62 C65 C72 H75
BS02 ZN A C102 C105 C233 C236 C102 C105 C201 C204
Gene Ontology
Molecular Function
GO:0001054 RNA polymerase I activity
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:1990841 promoter-specific chromatin binding
Biological Process
GO:0006351 DNA-templated transcription
GO:0006360 transcription by RNA polymerase I
GO:0006361 transcription initiation at RNA polymerase I promoter
GO:0006362 transcription elongation by RNA polymerase I
GO:0006363 termination of RNA polymerase I transcription
GO:0042254 ribosome biogenesis
GO:0042790 nucleolar large rRNA transcription by RNA polymerase I
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005736 RNA polymerase I complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c2m, PDBe:4c2m, PDBj:4c2m
PDBsum4c2m
PubMed24153182
UniProtP10964|RPA1_YEAST DNA-directed RNA polymerase I subunit RPA190 (Gene Name=RPA190)

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