Structure of PDB 4c21 Chain A

Receptor sequence
>4c21A (length=587) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence]
IQHPRIGIRPTIDGRRQGVRESLEVQTMNMAKSVADLISSTLKYPDGEPV
ECVISPSTIGRVPEAAASHELFKKSNVCATITVTPCWCYGSETMDMSPDI
PHAIWGFNGTERPGAVYLAAVLASHAQKGIPAFGIYGRDVQEASDTDIPE
DVKEKLLRYARAALATGLMRDTAYLSMGSVSMGIGGSIVNPDFFQEYLGM
RNESVDMTEFTRRMDRGIYDPEEFERALKWVKENVKEGFDHNREDLVLSR
EEKDRQWEFVIKMFMIGRDLMVGNPRLAELGFEEEAVGHHALVAGFQGQR
QWTDHFPNGDFMETFLNTQFDWNGIRKPFVFATENDSLNGVSMLFNYLLT
NTPQIFADVRTYWSPEAVKRVTGHTLEGRAAAGFLHLINSGSCTLDGTGQ
ATRDGKPIMKPFWELEESEVQAMLENTDFPPANREYFRGGGFSTRFLTKG
DMPVTMVRLNLLKGVGPVLQIAEGYTLELPEDVHHTLDNRTDPGWPTTWF
APRLTGKGAFKSVYDVMNNWGANHGAITYGHIGADLITLASMLRIPVNMH
NVPEEDIFRPKNWSLFGTEDLESADYRACQLLGPLHK
3D structure
PDB4c21 Structural and Functional Analysis of Fucose-Processing Enzymes from Streptococcus Pneumoniae.
ChainA
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E335 D359 H525
Catalytic site (residue number reindexed from 1) E334 D358 H524
Enzyme Commision number 5.3.1.25: L-fucose isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A E335 D359 H525 E334 D358 H524
BS02 FOC A M183 Q300 E335 D359 S391 Y437 N524 H525 M182 Q299 E334 D358 S390 Y436 N523 H524
Gene Ontology
Molecular Function
GO:0008736 L-fucose isomerase activity
GO:0008790 arabinose isomerase activity
GO:0016853 isomerase activity
GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0005996 monosaccharide metabolic process
GO:0006004 fucose metabolic process
GO:0019317 fucose catabolic process
GO:0019571 D-arabinose catabolic process
GO:0042355 L-fucose catabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4c21, PDBe:4c21, PDBj:4c21
PDBsum4c21
PubMed24333485
UniProtQ97N97|FUCI_STRPN L-fucose isomerase (Gene Name=fucI)

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