Structure of PDB 4c1m Chain A

Receptor sequence
>4c1mA (length=101) Species: 9606 (Homo sapiens) [Search protein sequence]
QDKYRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKR
NGFPVALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTPEP
A
3D structure
PDB4c1m Potent Reversible Inhibition of Myeloperoxidase by Aromatic Hydroxamates
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q91 D94 H95 D96
Catalytic site (residue number reindexed from 1) Q88 D91 H92 D93
Enzyme Commision number 1.11.2.2: myeloperoxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM A M87 G90 Q91 D94 D98 F99 T100 M84 G87 Q88 D91 D95 F96 T97
BS02 NIH A Q91 H95 Q88 H92 MOAD: Kd=15.8nM
BindingDB: Kd=15.8nM,IC50=5.01nM
Gene Ontology
Molecular Function
GO:0004601 peroxidase activity
GO:0020037 heme binding
Biological Process
GO:0006979 response to oxidative stress

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Molecular Function
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Biological Process
External links
PDB RCSB:4c1m, PDBe:4c1m, PDBj:4c1m
PDBsum4c1m
PubMed24194519
UniProtP05164|PERM_HUMAN Myeloperoxidase (Gene Name=MPO)

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