Structure of PDB 4c11 Chain A

Receptor sequence
>4c11A (length=593) Species: 12637 (Dengue virus) [Search protein sequence]
PETPNMDVIGERIKRIKEEHNSTWHYDDENPYKTWAYHGSYEVKATGSAS
SMINGVVKLLTKPWDVVPMVTQMAMTDTTPFGQQRVFKEKVDTRTPRPLP
GTRKVMEITAEWLWRTLGRNKRPRLCTREEFTKKVRTNASAKAAVEDEEF
WKLVDRERELHKLGKCGSCVYNMKSRAIWYMWLGVRYLEFEALGFLNEDH
WFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRITEDD
LHNEEKIIQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPTGTVMDIISRK
DQRGSGQVGTYGLNTFTNMEAQLVRQMEGEGVLTKADLENPHLLEKKITQ
WLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKDIPQWQ
PSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARISQGAG
WSLRETACLGKAYAQMWSLMYFHRRDLRLASNAICSAVPVHWVPTSRTTW
SIHAHHQWMTTEDMLTVWNRVWIEENPWMEDKTPVTTWENVPYLGKREDQ
WCGSLIGLTSRATWAQNIPTAIQQVRSLIGNEEFLDYMPSMKR
3D structure
PDB4c11 A Crystal Structure of the Dengue Virus Ns5 Polymerase Delineates Inter-Domain Amino Acids Residues that Enhance its Thermostability and De Novo Initiation Activities.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H712 H714 C728 C847 H417 H419 C433 C552
BS02 ZN A E437 H441 C446 C449 E157 H161 C166 C169
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:4c11, PDBe:4c11, PDBj:4c11
PDBsum4c11
PubMed24025331
UniProtQ6YMS4|POLG_DEN3S Genome polyprotein (Gene Name=pol)

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