Structure of PDB 4bzq Chain A

Receptor sequence
>4bzqA (length=173) Species: 1773 (Mycobacterium tuberculosis) [Search protein sequence]
PPRGKTVWFTGLSGSGKSSVAMLVERKLLEKGISAYVLDGDNLRHGLNAD
LGFSMADRAENLRRLSHVATLLADCGHLVLVPAISPLAEHRALARKVHAD
AGIDFFEVFCDTPLQDCERRDPKGLYAKARAGEITHFTGIDSPYQRPKNP
DLRLTPDRSIDEQAQEVIDLLES
3D structure
PDB4bzq Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium Tuberculosis.
ChainA
Resolution2.1 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.25: adenylyl-sulfate kinase.
2.7.7.4: sulfate adenylyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADX A D480 R483 F492 R497 N500 L501 A522 I523 K562 H575 F576 T577 D41 R44 F53 R58 N61 L62 A83 I84 K123 H136 F137 T138
BS02 ADP A G453 S454 G455 K456 S457 S458 R559 P561 R597 I599 Q602 G14 S15 G16 K17 S18 S19 R120 P122 R158 I160 Q163
Gene Ontology
Molecular Function
GO:0004020 adenylylsulfate kinase activity
GO:0005524 ATP binding
Biological Process
GO:0000103 sulfate assimilation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4bzq, PDBe:4bzq, PDBj:4bzq
PDBsum4bzq
PubMed25807013
UniProtP9WNM5|CYSNC_MYCTU Bifunctional enzyme CysN/CysC (Gene Name=cysNC)

[Back to BioLiP]