Structure of PDB 4bzb Chain A

Receptor sequence

>4bzbA (length=481) Species: 9606 (Homo sapiens) [Search protein sequence]

DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASH
NRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGP
FSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPE
EDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFAR
DCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNS
LHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEA
YTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKI
KREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHV
SFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQY
FVQWCADRNFTKPQDGDVIAPLITPQKKEWN

3D structure

PDB

4bzb Mechanism of Allosteric Activation of Samhd1 by Dgtp

Chain

Resolution

1.83 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.1.5.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	DGT	A	Q149 L150 R164 H215 H233 K312 Y315 D319 R366 Y374 Q375	Q37 L38 R52 H103 H121 K194 Y197 D201 R248 Y256 Q257
BS02	DGT	A	V156 F157 I325 R372 H376 K377	V44 F45 I207 R254 H258 K259
BS03	DGT	A	Y155 V156 V378 R451 K455	Y43 V44 V260 R333 K337
BS04	DGT	A	R333 R352 K354 K523	R215 R234 K236 K405
BS05	DGT	A	V117 N119	V5 N7
BS06	DGT	A	K116 I118 D137 R145	K4 I6 D25 R33

External links

PDB	RCSB:4bzb, PDBe:4bzb, PDBj:4bzb
PDBsum	4bzb
PubMed	24141705
UniProt	Q9Y3Z3\|SAMH1_HUMAN Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (Gene Name=SAMHD1)

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