Structure of PDB 4bw4 Chain A

Receptor sequence
>4bw4A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4bw4 Naphthyridines as Novel Bet Family Bromodomain Inhibitors.
ChainA
Resolution1.67 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 9B6 A W81 P82 F83 L92 N140 I146 M149 W40 P41 F42 L51 N99 I105 M108 MOAD: ic50=631nM
PDBbind-CN: -logKd/Ki=6.20,IC50=0.63uM
External links
PDB RCSB:4bw4, PDBe:4bw4, PDBj:4bw4
PDBsum4bw4
PubMed24000170
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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