Structure of PDB 4bw2 Chain A

Receptor sequence
>4bw2A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB4bw2 Naphthyridines as Novel Bet Family Bromodomain Inhibitors.
ChainA
Resolution1.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UTH A W81 F83 L92 N140 I146 W40 F42 L51 N99 I105 MOAD: ic50=6.31uM
PDBbind-CN: -logKd/Ki=5.20,IC50=6.31uM
External links
PDB RCSB:4bw2, PDBe:4bw2, PDBj:4bw2
PDBsum4bw2
PubMed24000170
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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