Structure of PDB 4bub Chain A

Receptor sequence
>4bubA (length=478) Species: 2336 (Thermotoga maritima) [Search protein sequence]
MNISTIVSNLKDLILEVRAPYDLEITGVSNHSSKVKKGDLFICRREIIPE
VMEKGAVAVVVEREIDLDFPYIQVFDSRYFEAKVASLFFEDPWKDVLTFG
VTGTNGKTTTTMMIYHMLTSLGERGSVLTTAVKRILGNSYYDDITTPDAI
TILSAMKENREGGGKFFALEVSSHALVQQRVEGVRFDVGIFTNISRDHLD
FHGTFENYLKAKLHLFDLLKDDGVAVLNESLADAFNRKSRKITFGTSKNA
DYRLGNIEVSWEGTQFVLETPDGLLKVFTRAIGDFNAYNAAAAIAALHQL
GYDPKDLASSLETFTGVEGRFEVVRGAKKIGLNVVVDFAHSPDALEKLLK
NVRKISQGRVIVVFGAGGNSDRGKRPMMSEVASKLADVVILTTDDPRGED
PEQIMEDLIKGIDKRKPYLVLFDRREAIETALTIANRGDSVVIAGRGHER
YQIIDEEKKVPFQDREVVEEIIRDKLKG
3D structure
PDB4bub Mreb and Murg as Scaffolds for the Cytoplasmic Steps of Peptidoglycan Biosynthesis
ChainA
Resolution2.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K114 T115 E165
Catalytic site (residue number reindexed from 1) K107 T108 E158
Enzyme Commision number 6.3.2.37: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase.
6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N112 G113 K114 T115 N200 F292 N296 R327 K354 N105 G106 K107 T108 N193 F285 N289 R320 K347
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004326 tetrahydrofolylpolyglutamate synthase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0016881 acid-amino acid ligase activity
GO:0047482 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity
GO:0102195 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--D-lysine ligase activity
Biological Process
GO:0008360 regulation of cell shape
GO:0009058 biosynthetic process
GO:0009252 peptidoglycan biosynthetic process
GO:0009396 folic acid-containing compound biosynthetic process
GO:0046901 tetrahydrofolylpolyglutamate biosynthetic process
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bub, PDBe:4bub, PDBj:4bub
PDBsum4bub
PubMed23826965
UniProtQ9WY79|MURE_THEMA UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--LD-lysine ligase (Gene Name=murE)

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