Structure of PDB 4br3 Chain A

Receptor sequence
>4br3A (length=354) Species: 9606 (Homo sapiens) [Search protein sequence]
DEQPEPRTRRRAYLWCKEFLPGAWRGLREDEFHISVIRGGLSNMLFQCSL
PDTTATLGDEPRKVLLRLYGAEAMVLESVMFAILAERSLGPKLYGIFPQG
RLEQFIPSRRLDTEELSLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTM
EKYLKEVLRIKFTEESRIKKLHKLLSYNLPLELENLRSLLESTPSPVVFC
HNDCQEGNILLLEGRENSEKQKLMLIDFEYSSYNYRGFDIGNHFCEWMYD
YSYEKYPFFRANIRKYPTKKQQLHFISSYLPAFQNDFENLSTEEKSIIKE
EMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMDYAQARFDAYFHQKR
KLGV
3D structure
PDB4br3 Determination of Potential Scaffolds for Human Choline Kinase Alpha 1 by Chemical Deconvolution Studies
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.32: choline kinase.
2.7.1.82: ethanolamine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 U85 A R117 D306 Q308 Y333 Y354 W420 W423 F435 Y440 R38 D203 Q205 Y230 Y251 W317 W320 F332 Y337 MOAD: Kd=1.9uM
PDBbind-CN: -logKd/Ki=5.72,Kd=1.9uM
BS02 A4V A I116 L144 Q207 I209 S211 R213 I37 L65 Q104 I106 S108 R110
External links
PDB RCSB:4br3, PDBe:4br3, PDBj:4br3
PDBsum4br3
PubMed23813777
UniProtP35790|CHKA_HUMAN Choline kinase alpha (Gene Name=CHKA)

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