Structure of PDB 4bqy Chain A

Receptor sequence
>4bqyA (length=221) Species: 9606 (Homo sapiens) [Search protein sequence]
LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTD
GQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKL
GSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAK
VSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAIT
VWYFDADERARAKVKYLVRVE
3D structure
PDB4bqy Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
ChainA
Resolution1.53 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H313 D315 H374 H126 D128 H187
BS02 FNT A D254 M299 Y303 Y310 H313 I327 Y329 L343 H374 V376 R383 D67 M112 Y116 Y123 H126 I140 Y142 L156 H187 V189 R196 PDBbind-CN: -logKd/Ki=5.96,IC50=1.1uM
BindingDB: IC50=512nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:4bqy, PDBe:4bqy, PDBj:4bqy
PDBsum4bqy
PubMed23683440
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

[Back to BioLiP]