Structure of PDB 4bp9 Chain A

Receptor sequence

>4bp9A (length=710) Species: 5691 (Trypanosoma brucei)

RGPIAAHRPHEVVFGKVEGEDRGANPMDPPRRRVDPLFWLRDDNRADPEV
LAHLHLEKDYYEKRAVDIKDLAETIYQEHISHIEETDMSAPYVYDRFLYY
TRDVKGLSYKLHCRVPAGKTPGEGEDEEIVLDENKLAEGKSFCVVGCVAP
APPEHALVAYSVDYCGDEVYSIRFVRDVVADKVEGTNGSVVWGPNAECFF
YITKDASKRDNKVWRHIIGQPQSEDVCLYTDDDPLFSVGVGRSGDGKTLI
ICSMSSETSESHLLDLRKGVKHNTLEMVRPREKGVRYTVEMHGTDTLIVL
TNKDKCVNGKVVLTKRSAPTDWGTVLIPHDDKVTIDDVAVFAKFAVLSGR
RDGLTRVWTVRLGPDNLFSSATLKELHFDEPVFTAHVVCSQMKTYDASLL
RLRYSSMTTPTVWYDEDVLSGERKVVKARKVGGGFESKNYVCRRELATAP
DGTKVPISLVYDTSIDLKKPNPTMLYGYGSYGICIEPEFNSRFLPYVDRG
MIYAIAHVRGGGEMGRTWYEVGGKYLTKRNTFMDFIACAEHLISSGLTTP
AQLSCEGRSAGGLLVGAVLNMRPDLFHVALAGVPFVDVMTTMCDPSIPLT
TGEWEEWGNPNEYKFFDYMNSYSPIDNVRAQDYPHLMIQAGLHDPRVAYW
EPAKWASKLRELKTDSNEVLLKMDLESGHFSASDRYKYLRENAIQQAFVL
KHLNVRQLLR

3D structure

• PDB: 4bp9 Crystal Structures of Trypanosoma Brucei Oligopeptidase B Broaden the Paradigm of Catalytic Regulation in Prolyl Oligopeptidase Family Enzymes.
• Chain: A
• Resolution: 2.85 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): Y482 S563 D648 H683
• Catalytic site (residue number reindexed from 1): Y478 S559 D644 H679
• Enzyme Commision number: 3.4.21.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	N191 K208 D214 Y485 S563 A564 F589 E607 R650 V651	N187 K204 D210 Y481 S559 A560 F585 E603 R646 V647

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:4bp9, PDBe:4bp9, PDBj:4bp9
• PDBsum: 4bp9
• PubMed: 24265767
• UniProt: O76728