Structure of PDB 4blb Chain A

Receptor sequence

>4blbA (length=734) Species: 9606,83333 [Search protein sequence]

MKTEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQ
VAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRY
NGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMF
NLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLI
KNKHMNADTDYSIAEHAFNHGETAMTINGPWAWSNIDTSKVNYGVTVLPT
FKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPL
GAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVIN
AASGRQTVDAALAAAQTNAAAPGLHAIYGECRRLYPDQPNPLQVTAIVKY
DSFGPDPLDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGT
DGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCSGDH
VSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHS
AQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEIDPHLQERVDKGIE
TDGSNLSGVSAKCAWDDRTRQLESVHLKFNQESGALIPLCLRGRLLHGRH
FTYKSITGDMAITFVSTGVEGAFATEEHPYAAHGPWLQILLTEEFVEKML
EDLEDAALPKEYSWPEKKLKVSILPDVVHHHHHH

3D structure

PDB

4blb Structural Basis of Sufu-GLI Interaction in Hedgehog Signalling Regulation

Chain

Resolution

2.8 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	Y487 F495 D499 H500 V501 S502 W503 N605 L606 S607 G608 V609 S610 E641	Y487 F495 D499 H500 V501 S502 W503 N605 L606 S607 G608 V609 S610 E632
BS02	GLC	A	D15 K16 E112 Y156	D15 K16 E112 Y156
BS03	GLC	A	W63 D66 R67 E154 Y156 W341	W63 D66 R67 E154 Y156 W341
BS04	ZN	A	H751 H753	H732 H734
BS05	ZN	A	H216 E222	H216 E222

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0015144	carbohydrate transmembrane transporter activity
GO:1901982	maltose binding

	Biological Process
GO:0006974	DNA damage response
GO:0008643	carbohydrate transport
GO:0015768	maltose transport
GO:0034219	carbohydrate transmembrane transport
GO:0034289	detection of maltose stimulus
GO:0042956	maltodextrin transmembrane transport
GO:0055085	transmembrane transport
GO:0060326	cell chemotaxis

	Cellular Component
GO:0016020	membrane
GO:0030288	outer membrane-bounded periplasmic space
GO:0042597	periplasmic space
GO:0043190	ATP-binding cassette (ABC) transporter complex
GO:0055052	ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing
GO:1990060	maltose transport complex

View graph for
Molecular Function

View graph for
Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:4blb, PDBe:4blb, PDBj:4blb
PDBsum	4blb
PubMed	24311597
UniProt	P0AEX9\|MALE_ECOLI Maltose/maltodextrin-binding periplasmic protein (Gene Name=malE); Q9UMX1\|SUFU_HUMAN Suppressor of fused homolog (Gene Name=SUFU)

[Back to BioLiP]