Structure of PDB 4bk1 Chain A

Receptor sequence

>4bk1A (length=389) Species: 101510 (Rhodococcus jostii RHA1) [Search protein sequence]

NLQDARIIIAGGGIGGAANALALAQKGANVTLFERASEFGEVGAGLQVGP
HGARILDSWGVLDDVLSRAFLPKNIVFRDAITAEVLTKIDLGSEFRGRYG
GPYFVTHRSDLHATLVDAARAAGAELHTGVTVTDVITEGDKAIVSTDDGR
THEADIALGMDGLKSRLREKISGDEPVSSGYAAYRGTTPYEDIEDVVGYI
GPRCSFIQYPLRGGEMLNQVAVFESPGFKNGIENWGGPEELEQAYAHCHE
NVRRGIDYLWKDRWWPMYDREPIENWVDGRMILLGDAAHPPLQYLASGAV
MAIEDAKCLADYAAEDFSTGGNSAWPQILKEVNTERAPRCNRILTTGRMW
GELWHLDGTARIARNELFRTRDTSSYKYTDWLWGYSSDR

3D structure

PDB

4bk1 Crystal Structure of 3-Hydroxybenzoate 6-Hydroxylase Uncovers Lipid-Assisted Flavoprotein Strategy for Regioselective Aromatic Hydroxylation

Chain

Resolution

1.73 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

1.14.13.1: salicylate 1-monooxygenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FAD	A	G13 G15 G17 F35 E36 R37 L48 Q49 R110 T133 V134 M162 D163 G164 R187 D294 Q301 A304 S305 G306 A307 V308	G11 G13 G15 F33 E34 R35 L46 Q47 R108 T131 V132 M160 D161 G162 R185 D286 Q293 A296 S297 G298 A299 V300
BS02	P3A	A	I91 T354 W358 L361 K385 Y386 W389	I89 T346 W350 L353 K377 Y378 W381
BS03	3HB	A	Q49 I215 Y217 Q301	Q47 I207 Y209 Q293	BindingDB: Kd=4.8e+4nM
BS04	CL	A	Q301 G306	Q293 G298

Gene Ontology

	Molecular Function
GO:0000166	nucleotide binding
GO:0004497	monooxygenase activity
GO:0018658	salicylate 1-monooxygenase activity
GO:0071949	FAD binding

View graph for
Molecular Function

External links

PDB	RCSB:4bk1, PDBe:4bk1, PDBj:4bk1
PDBsum	4bk1
PubMed	23864660
UniProt	Q0SFK6

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