Structure of PDB 4bjc Chain A

Receptor sequence
>4bjcA (length=197) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAGI
YFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSFLQ
FSHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLITYQIMRPE
3D structure
PDB4bjc Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RPB A H1031 G1032 Y1060 F1061 A1062 K1067 S1068 Y1071 E1138 H80 G81 Y101 F102 A103 K108 S109 Y112 E174 MOAD: ic50=14nM
PDBbind-CN: -logKd/Ki=7.85,IC50=14nM
BindingDB: IC50=890nM
BS02 ZN A C1081 H1084 C1089 C1092 C122 H125 C130 C133
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4bjc, PDBe:4bjc, PDBj:4bjc
PDBsum4bjc
PubMed24900770
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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