Structure of PDB 4bj9 Chain A

Receptor sequence
>4bj9A (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]
GTILIDLSPDDKEFQSVEEEMQSTVREHRDGGHAGGIFNRYNILKIQKVC
NKKLWERYTHRRKEVSEENHNHANERMLFHGSPFVNAIIHKGFDERHAYI
GGMFGAGIYFAENSSKSNQYVYGIGGGTGCPVHKDRSCYICHRQLLFCRV
TLGKSFLQFSAAHSPPGHHSVTGRPSVNGLALAEYVIYRGEQAYPEYLIT
YQIMRPE
3D structure
PDB4bj9 Evaluation and Structural Basis for the Inhibition of Tankyrases by Parp Inhibitors
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C1081 H1084 C1089 C1092 C130 H133 C138 C141
BS02 UHB A H1031 G1032 S1033 F1035 I1039 H1048 A1049 I1051 G1058 Y1060 S1068 Y1071 H80 G81 S82 F84 I88 H97 A98 I100 G107 Y109 S117 Y120 MOAD: ic50=45nM
PDBbind-CN: -logKd/Ki=7.35,IC50=45nM
Gene Ontology
Molecular Function
GO:0003950 NAD+-protein poly-ADP-ribosyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4bj9, PDBe:4bj9, PDBj:4bj9
PDBsum4bj9
PubMed24900770
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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