Structure of PDB 4bix Chain A

Receptor sequence
>4bixA (length=229) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
AAGASFNQVVTALERMMTSQQRLLSDISHELRTPLTRLQLGTALLRRRSG
ESKELERIETEAQRLDSMINDLLVMSRNQQKNALVSETIKANQLWSEVLD
NAAFEAEQMGKSLTVNFPPGPWPLYGNPNALESALENIVRNALRYSHTKI
EVGFAVDKDGITITVDDDGPGVSPEDREQIFRPFYRTDGTGLGLAIVETA
IQQHRGWVKAEDSPLGGLRLVIWLPLYKR
3D structure
PDB4bix Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.13.3: histidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A N360 Y364 G390 V391 Y404 G420 L421 L445 N141 Y145 G171 V172 Y185 G193 L194 L218
BS02 MG A R363 Y364 R144 Y145
Gene Ontology
Molecular Function
GO:0000155 phosphorelay sensor kinase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0007165 signal transduction
GO:0016310 phosphorylation
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bix, PDBe:4bix, PDBj:4bix
PDBsum4bix
PubMed24492262
UniProtP0AE82|CPXA_ECOLI Sensor histidine kinase CpxA (Gene Name=cpxA)

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