Structure of PDB 4bie Chain A

Receptor sequence
>4bieA (length=257) Species: 9606 (Homo sapiens) [Search protein sequence]
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPELHEEIA
LHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNE
QTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSK
RLAGEFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYE
LGEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLL
VDEFLKV
3D structure
PDB4bie Crystal Structures of Ask1-Inhibtor Complexes Provide a Platform for Structure Based Drug Design.
ChainA
Resolution2.36 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D126 K128 D130 N131 D145 T159
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IE6 A G687 K688 G689 V694 A707 K709 Q756 V757 N808 L810 D822 G18 K19 G20 V25 A38 K40 Q79 V80 N131 L133 D145 MOAD: ic50=0.79uM
PDBbind-CN: -logKd/Ki=6.60,IC50=0.25uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4bie, PDBe:4bie, PDBj:4bie
PDBsum4bie
PubMed23776076
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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