Structure of PDB 4bid Chain A

Receptor sequence
>4bidA (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPELHEEIA
LHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNE
QTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSK
REEFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELG
EPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLVD
EFLK
3D structure
PDB4bid Crystal Structures of Ask1-Inhibtor Complexes Provide a Platform for Structure Based Drug Design.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D126 K128 D130 N131 D145 T157
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IE8 A L686 G687 V694 A707 K709 V738 I752 M754 E755 V757 D807 N808 L810 D822 L17 G18 V25 A38 K40 V61 I75 M77 E78 V80 D130 N131 L133 D145 PDBbind-CN: -logKd/Ki=8.10,IC50=7.94nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4bid, PDBe:4bid, PDBj:4bid
PDBsum4bid
PubMed23776076
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

[Back to BioLiP]