Structure of PDB 4bhw Chain A

Receptor sequence

>4bhwA (length=563) Species: 9606 (Homo sapiens)

KKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKS
PMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKL
SEVFEQEIDPVMQSLGYCCGRKLEFSPQTLCCYGKQLCTIPRDATYYSYQ
NRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFV
ECTECGRKMHQICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPS
TRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVD
SGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYI
SYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIWACPPSEGDD
YIFHCHPPDQKIPKPKRLQEWFKKMLDKAVSERIVHDYKDIFKQATEDRL
TSAKELPYFEGDFWPNVLEESIKESGGSGSQKLYATMEKHKEVFFVIRLI
AGPAANSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWST
MCMLVELHTQSQD

3D structure

• PDB: 4bhw Structure of the P300 Catalytic Core and Implications for Chromatin Targeting and Hat Regulation
• Chain: A
• Resolution: 2.799 Å

Enzymatic activity

• Enzyme Commision number: 2.3.1.-
  2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C1163 C1164 H1255 C1258	C118 C119 H210 C213
BS02	ZN	A	C1247 C1250 C1272	C202 C205 C227
BS03	ZN	A	C1201 C1204	C156 C159
BS04	ZN	A	H1315 C1408	H270 C363
BS05	01K	A	Y1397 L1398 D1399 S1400 R1410 T1411 Y1414 W1436 C1438 P1440 Y1446 K1456 I1457 P1458 R1462 W1466 F1467	Y352 L353 D354 S355 R365 T366 Y369 W391 C393 P395 Y401 K411 I412 P413 R417 W421 F422

Gene Ontology

Molecular Function

• GO:0004402 histone acetyltransferase activity

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:4bhw, PDBe:4bhw, PDBj:4bhw
• PDBsum: 4bhw
• PubMed: 23934153
• UniProt: Q09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)