Structure of PDB 4bhn Chain A

Receptor sequence
>4bhnA (length=256) Species: 9606 (Homo sapiens) [Search protein sequence]
LLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPEPLHEEI
ALHKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDN
EQTIGFYTKQILEGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTS
KRLEFTGTLQYMAPEIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYEL
GEPQAAMFKVGMFKVHPEIPESMSAEAKAFILKCFEPDPDKRACANDLLV
DEFLKV
3D structure
PDB4bhn Crystal Structures of Ask1-Inhibtor Complexes Provide a Platform for Structure Based Drug Design.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D803 K805 D807 N808 D822 T842
Catalytic site (residue number reindexed from 1) D127 K129 D131 N132 D146 T158
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BH9 A L686 V694 A707 K709 M754 Q756 V757 G759 G760 L810 L17 V25 A38 K40 M78 Q80 V81 G83 G84 L134 MOAD: ic50=13nM
PDBbind-CN: -logKd/Ki=8.20,IC50=6.31nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4bhn, PDBe:4bhn, PDBj:4bhn
PDBsum4bhn
PubMed23776076
UniProtQ99683|M3K5_HUMAN Mitogen-activated protein kinase kinase kinase 5 (Gene Name=MAP3K5)

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