Structure of PDB 4bfw Chain A

Receptor sequence
>4bfwA (length=306) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVEEVYLPL
ARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVGKSTT
ARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNRR
ALMRFVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNVL
QTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADPESHFHH
YAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDADHSINR
LRLRKL
3D structure
PDB4bfw Structural and Biochemical Characterization of Compounds Inhibiting Mycobacterium Tuberculosis Pank
ChainA
Resolution2.27 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZVW A H179 Y182 L203 Y235 R238 M242 F254 I272 I276 N277 H173 Y176 L197 Y229 R232 M236 F248 I266 I270 N271 MOAD: ic50=0.05uM
BindingDB: IC50=5e+1nM
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4bfw, PDBe:4bfw, PDBj:4bfw
PDBsum4bfw
PubMed23661699
UniProtP9WPA7|COAA_MYCTU Pantothenate kinase (Gene Name=coaA)

[Back to BioLiP]