Structure of PDB 4bfu Chain A

Receptor sequence
>4bfuA (length=306) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
PSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVEEVYLPL
ARLIHLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVGKSTT
ARVLQALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNRR
ALMRFVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNVL
QTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADPESHFHH
YAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDADHSINR
LRLRKL
3D structure
PDB4bfu Structural and Biochemical Characterization of Compounds Inhibiting Mycobacterium Tuberculosis Pank
ChainA
Resolution2.28 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZVU A D129 L132 K147 Y177 Y182 L203 Y235 R238 F239 M242 N277 D123 L126 K141 Y171 Y176 L197 Y229 R232 F233 M236 N271 MOAD: ic50=0.15uM
BindingDB: IC50=1.5e+2nM
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bfu, PDBe:4bfu, PDBj:4bfu
PDBsum4bfu
PubMed23661699
UniProtP9WPA7|COAA_MYCTU Pantothenate kinase (Gene Name=coaA)

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