Structure of PDB 4bfs Chain A

Receptor sequence
>4bfsA (length=302) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
EPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVEEVYLP
LARLIHLQVAARQRLFAATAEFLGEPRPVPFIIGVAGSVAVGKSTTARVL
QALLARWDHHPRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNRRALMR
FVTSVKSGSDYACAPVYSHLHYDIIPGAEQVVRHPDILILEGLNVLQTGP
TLMVSDLFDFSLYVDARIEDIEQWYVSRFLAMRTTAFADPESHFHHYAAF
SDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDADHSINRLRLR
KL
3D structure
PDB4bfs Structural and Biochemical Characterization of Compounds Inhibiting Mycobacterium Tuberculosis Pank
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZVS A H179 Y182 Y235 R238 M242 F254 I272 I276 H169 Y172 Y225 R228 M232 F244 I262 I266 BindingDB: IC50=9e+1nM
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bfs, PDBe:4bfs, PDBj:4bfs
PDBsum4bfs
PubMed23661699
UniProtP9WPA7|COAA_MYCTU Pantothenate kinase (Gene Name=coaA)

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