Structure of PDB 4bfm Chain A

Receptor sequence
>4bfmA (length=313) Species: 10090 (Mus musculus) [Search protein sequence]
KDYDELLKYYELYETIGTGGFAKVKLACHVLTGEMVAIKIMDKNALGSDL
PRVKTEIDALKSLRHQHICQLYHVLETKNKIFMVLEYCPGGELFDYIISQ
DRLSEEETRVVFRQILSAVAYVHSQGYAHRDLKPENLLFDENHKLKLIDF
GLCAKCGSLAYAAPELIQGSEADVWSMGILLYVLMCGFLPFDDDNVMALY
KKIMRGKYEVPKWLSPSSILLLQQMLQVDPKKRISMRNLLNHPWVMQDYS
CPVEWQSKTPLTHLDEDCVTELSVHHRSSRQTMEDLISSWQYDHLTATYL
LLLAKKARLEHHH
3D structure
PDB4bfm The Structures of the Kinase Domain and Uba Domain of Mpk38 Suggest the Activation Mechanism for Kinase Activity.
ChainA
Resolution2.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D132 K134 E136 N137 D150 S171
Catalytic site (residue number reindexed from 1) D131 K133 E135 N136 D149 S158
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A I17 T19 G20 G21 F22 A23 A38 K40 C89 E93 L139 D150 I16 T18 G19 G20 F21 A22 A37 K39 C88 E92 L138 D149
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4bfm, PDBe:4bfm, PDBj:4bfm
PDBsum4bfm
PubMed24531485
UniProtQ61846|MELK_MOUSE Maternal embryonic leucine zipper kinase (Gene Name=Melk)

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