Structure of PDB 4bcr Chain A

Receptor sequence
>4bcrA (length=263) Species: 9606 (Homo sapiens) [Search protein sequence]
KSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKT
LVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLN
DQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCD
IMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEG
IVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESD
AALHPLLQEIYRD
3D structure
PDB4bcr Molecular Mechanism of Peroxisome Proliferator-Activated Receptor Alpha Activation by Wy14643: A New Mode of Ligand Recognition and Receptor Stabilization
ChainA
Resolution2.497 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WY1 A C276 T279 S280 Y314 F318 L321 M330 M355 K358 C73 T76 S77 Y111 F115 L118 M127 M152 K155 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
BS02 WY1 A E251 L258 R271 I272 H274 C275 E48 L55 R68 I69 H71 C72 BindingDB: EC50=1600nM,Kd=0.360000nM,IC50=10110nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:4bcr, PDBe:4bcr, PDBj:4bcr
PDBsum4bcr
PubMed23707408
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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