Structure of PDB 4bcj Chain A

Receptor sequence
>4bcjA (length=310) Species: 9606 (Homo sapiens) [Search protein sequence]
DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE
KEGFPITALREIKILQLLKHENVVNLIEICRTKKGSIYLVFDFCEHDLAG
LLSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGV
LKLADFGLARAFSLAPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAG
CIMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLE
LVKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFW
SDPMPSDLKG
3D structure
PDB4bcj Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
ChainA
Resolution3.162 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 A153 N154 D167 T191
Catalytic site (residue number reindexed from 1) D137 K139 A141 N142 D155 T175
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T9N A F30 A46 V79 F103 C106 E107 H108 D109 L156 F25 A41 V74 F91 C94 E95 H96 D97 L144 PDBbind-CN: -logKd/Ki=7.96,Ki=11nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4bcj, PDBe:4bcj, PDBj:4bcj
PDBsum4bcj
PubMed23252711
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

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