Structure of PDB 4bci Chain A

Receptor sequence
>4bciA (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
YDSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMEN
EKEGFPITALREIKILQLLKHENVVNLIEICRTGSIYLVFDFCEHDLAGL
LSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL
KLADFGLARAFSLAPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGC
IMAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLEL
VKGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWS
DPMPSDLKG
3D structure
PDB4bci Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
ChainA
Resolution3.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 A153 N154 D167 T191
Catalytic site (residue number reindexed from 1) D136 K138 A140 N141 D154 T174
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T3E A I25 F30 V79 F103 C106 E107 L156 I21 F26 V75 F90 C93 E94 L143 PDBbind-CN: -logKd/Ki=8.22,Ki=6nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4bci, PDBe:4bci, PDBj:4bci
PDBsum4bci
PubMed23252711
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

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