Structure of PDB 4bcf Chain A

Receptor sequence
>4bcfA (length=308) Species: 9606 (Homo sapiens) [Search protein sequence]
DSVECPFCDEVSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENE
KEGFPITALREIKILQLLKHENVVNLIEICRTKASIYLVFDFCEHDLAGL
LSNVLVKFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVL
KLADFGLARAFSLPNRYTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCI
MAEMWTRSPIMQGNTEQHQLALISQLCGSITPEVWPNVDNYELYEKLELV
KGQKRKVKDRLKAYVRDPYALDLIDKLLVLDPAQRIDSDDALNHDFFWSD
PMPSDLKG
3D structure
PDB4bcf Comparative Structural and Functional Studies of 4-(Thiazol- 5-Yl)-2-(Phenylamino)Pyrimidine-5-Carbonitrile Cdk9 Inhibitors Suggest the Basis for Isotype Selectivity.
ChainA
Resolution3.011 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D149 K151 A153 N154 D167 T191
Catalytic site (residue number reindexed from 1) D136 K138 A140 N141 D154 T173
Enzyme Commision number 2.7.11.22: cyclin-dependent kinase.
2.7.11.23: [RNA-polymerase]-subunit kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T6Q A F30 A46 V79 F103 C106 D109 A153 L156 D167 F25 A41 V74 F90 C93 D96 A140 L143 D154 PDBbind-CN: -logKd/Ki=8.15,Ki=7nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:4bcf, PDBe:4bcf, PDBj:4bcf
PDBsum4bcf
PubMed23252711
UniProtP50750|CDK9_HUMAN Cyclin-dependent kinase 9 (Gene Name=CDK9)

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