Structure of PDB 4bbj Chain A

Receptor sequence
>4bbjA (length=664) Species: 91891 (Legionella pneumophila subsp. pneumophila) [Search protein sequence]
VVSPEYLDMRRRFWIALMLTIPVVILEMGGHGLKHFISGNGSSWIQLLLA
TPVVLWGGWPFFKRGWQSLKTGQLNMFTLIAMGIGVAWIYSMVAVLWPGV
FPHAFRSQEGVVAVYFEAAAVITTLVLLGQVLELKAREQTGSAIRALLKL
VPESAHRIKEDGSEEEVSLDNVAVGDLLRVRPGEKIPVDGEVQEGRSFVD
ESMVTGEPIPVAKEASAKVIGATINQTGSFVMKALHVGSDTMLARIVQMV
SDAQRSRAPIQRLADTVSGWFVPAVILVAVLSFIVWALLGPQPALSYGLI
AAVSVLIIACPCALGLATPMSIMVGVGKGAQSGVLIKNAEALERMEKVNT
LVVDKTGTLTEGHPKLTRIVTDDFVEDNALALAAALEHQSEHPLANAIVH
AAKEKGLSLGSVEAFEAPTGKGVVGQVDGHHVAIGNARLMQEHGGDNAPL
FEKADELRGKGASVMFMAVDGKTVALLVVEDPIKSSTPETILELQQSGIE
IVMLTGDSKRTAEAVAGTLGIKKVVAEIMPEDKSRIVSELKDKGLIVAMA
GDGVNDAPALAKADIGIAMGTGTDVAIESAGVTLLHGDLRGIAKARRLSE
STMSNIRQNLFFAFIYNVLGVPLAAGVLYPLTGLLLSPMIAAAAMALSSV
SVIINALRLKRVTL
3D structure
PDB4bbj Copper-Transporting P-Type Atpases Use a Unique Ion-Release Pathway
ChainA
Resolution2.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D426 D624 D628
Catalytic site (residue number reindexed from 1) D354 D552 D556
Enzyme Commision number 7.2.2.8: P-type Cu(+) transporter.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A X426 T428 D624 X354 T356 D552
BS02 NAD A E459 H464 G492 G494 M537 E387 H392 G420 G422 M465
BS03 PC A R84 W128 W131 R12 W56 W59
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0005215 transporter activity
GO:0005507 copper ion binding
GO:0005524 ATP binding
GO:0015662 P-type ion transporter activity
GO:0016887 ATP hydrolysis activity
GO:0019829 ATPase-coupled monoatomic cation transmembrane transporter activity
GO:0043682 P-type divalent copper transporter activity
GO:0046872 metal ion binding
GO:0140581 P-type monovalent copper transporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006825 copper ion transport
GO:0006878 intracellular copper ion homeostasis
GO:0055070 copper ion homeostasis
GO:0060003 copper ion export
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:4bbj, PDBe:4bbj, PDBj:4bbj
PDBsum4bbj
PubMed24317491
UniProtQ5ZWR1|COPA_LEGPH Copper-exporting P-type ATPase (Gene Name=copA)

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