Structure of PDB 4bbg Chain A

Receptor sequence
>4bbgA (length=336) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTY
TFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTME
GERSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNE
ELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEK
GAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVDL
AGSENININQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRT
SIIATISPASLNLEETLSTLEYAHRAKNILNKPEVN
3D structure
PDB4bbg Optimized S-Trityl-L-Cysteine-Based Inhibitors of Kinesin Spindle Protein with Potent in Vivo Antitumor Activity in Lung Cancer Xenograft Models.
ChainA
Resolution2.75 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A R24 R26 P27 G108 G110 K111 T112 F113 E118 R8 R10 P11 G92 G94 K95 T96 F97 E102
BS02 V02 A E116 G117 E118 R119 A133 P137 E100 G101 E102 R103 A117 P121 PDBbind-CN: -logKd/Ki=8.32,Ki=4.8nM
BindingDB: Ki=4.8nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:4bbg, PDBe:4bbg, PDBj:4bbg
PDBsum4bbg
PubMed23394180
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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