Structure of PDB 4bb9 Chain A

Receptor sequence
>4bb9A (length=596) Species: 9606 (Homo sapiens) [Search protein sequence]
RFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQ
CDAEIFQESTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTS
GRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGI
EELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNP
VSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRM
KGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQS
PKIATLMKSVSTSLETTGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDV
RGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIF
TLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISIT
WPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRI
SNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCH
VQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALA
3D structure
PDB4bb9 Crystal Structure of Glucokinase Regulatory Protein.
ChainA
Resolution1.47 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 F1P A G107 G108 S110 E153 S179 V180 G181 E348 H351 N512 K514 G97 G98 S100 E143 S169 V170 G171 E338 H341 N502 K504 PDBbind-CN: -logKd/Ki=6.00,Kd=1uM
BS02 CA A E566 E568 E556 E558
Gene Ontology
Molecular Function
GO:0004857 enzyme inhibitor activity
GO:0005515 protein binding
GO:0019210 kinase inhibitor activity
GO:0019899 enzyme binding
GO:0030246 carbohydrate binding
GO:0070095 fructose-6-phosphate binding
GO:0097367 carbohydrate derivative binding
GO:0141089 glucose sensor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0009749 response to glucose
GO:0009750 response to fructose
GO:0033132 negative regulation of glucokinase activity
GO:0042593 glucose homeostasis
GO:0046415 urate metabolic process
GO:0070328 triglyceride homeostasis
GO:1901135 carbohydrate derivative metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4bb9, PDBe:4bb9, PDBj:4bb9
PDBsum4bb9
PubMed23621087
UniProtQ14397|GCKR_HUMAN Glucokinase regulatory protein (Gene Name=GCKR)

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