Structure of PDB 4bac Chain A

Receptor sequence

>4bacA (length=368) Species: 11963 (Human spumaretrovirus)

LDAELDQLLQGHYIKGYPKQYTYFLEDGKVKVSRPEGVKIIPPQSDRQKI
VLQAHNLAHTGREATLLKIANLYWWPNMRKDVVKQLGRCQQCLITNASNK
ASGPILRPDRPQKPFDKFFIDYIGPLPPSQGYLYVLVVVDGMTGFTWLYP
TKAPSTSATVKSLNVLTSIAIPKVIHSDQGAAFTSSTFAEWAKERGIHLE
FSTPYHPQSGSKVERKNSDIKRLLTKLLVGRPTKWYDLLPVVQLALNNTY
SPVLKYTPHQLLFGIDSNTPFANQDTLDLTREEELSLLQEIRTSLYHPST
PPASSRSWSPVVGQLVQERVARPASLRPRWHKPSTVLKVLNPRTVVILDH
LGNNRTVSIDNLKPTSHQ

3D structure

• PDB: 4bac Assembly of Prototype Foamy Virus Strand Transfer Complexes on Product DNA Bypassing Catalysis of Integration.
• Chain: A
• Resolution: 3.263 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.26.4: ribonuclease H.
  3.4.23.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	I112 L113 R114 P115 E207 F208 S209 T210 Q215 S216 S218 R222 R229 S258 P259 L347 N348 R350 T351	I105 L106 R107 P108 E200 F201 S202 T203 Q208 S209 S211 R215 R222 S251 P252 L340 N341 R343 T344
BS02	dna	A	G131 P132 P214 Q215 E221 R222 S225 K228 K262	G124 P125 P207 Q208 E214 R215 S218 K221 K255
BS03	ZN	A	H62 H66 C99	H55 H59 C92
BS04	MG	A	D128 D185	D121 D178

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:4bac, PDBe:4bac, PDBj:4bac
• PDBsum: 4bac
• PubMed: 23011895
• UniProt: P14350|POL_FOAMV Pro-Pol polyprotein (Gene Name=pol)